Lab Publications


2024

Handoko K., Neppach A., Karim H.T.1,2, Dombrovski A.Y.,Peciña M. Mechanisms of long-term antidepressant placebo effects. (Under Review)

Mary L. Woody, PhD; Rebecca Rohac, BS; Iya Cooper, BS; Angela Griffo, BS; Nastasia McDonald, BS; Jay Fournier, PhD; Neil Jones, PhD; Peciña M, MD; Kymberly Young, PhD; Ben Grafton, PhD; Rebecca B. Price, PhD. The Impact of Intravenous Ketamine on Attentional Bias: Probing Mechanisms of Rapid-Acting Antidepressant Effects. (Under Review)

2023

Lin Z., Agabio R., Lopez-Pelayo H., Bruguera P., Huang SY., Peciña M, Krupitsky EM., Fitzmaurice GM. Baseline and placebo double-controlled pharmacoefficacy for alcohol use disorder per studies during 1979~2023. (Under Review)

Peciña M, Chen J, Lyew T, Karp JF, Dombrovski AY. Dynamic feedback between antidepressant placebo expectancies and mood: contributions of the dorsal attention and salience network (JAMA Psychiatry: in press).Publisher Link

2022

Gerlach A.R.; Karim H.T.; Peciña M, ; Ajilore O.; Taylor W.; Butters M.A.; Andreescu C. MRI Predictors of Pharmacotherapy Response in Major Depressive Disorder (Neuroimage: Clinical). Publisher Link

2021

Evans K., Colloca L., Peciña M, Katz N. What can be done to control the placebo response in clinical trials?: A narrative review. Contemp Clin Trials. Publisher Link

Peciña M, Chen J, Lyew T, Karp JF, Dombrovski AY. ยต-Opioid antagonist naltrexone partially abolishes the antidepressant placebo effect and reduces OFC encoding of reinforcement. Publisher Link

Peciña M, Dombrovski AY, Price R, Karim H. Understanding the Neurocomputational Mechanisms of Antidepressant Placebo Effects. Publisher Link

2020

Chen J; Mizuno A; Lyew T; Karim H; Karp JF; Dombrovski AY; and Peciña M. Naltrexone Modulates Contextual Processing in Depression. Neuropsychopharmacolgy. Publisher Link

2019

Stahl ST; Jung C; Weiner DK; Peciña M; and Karp J. Opioid Exposure Negatively Affects Antidepressant Response to Venlafaxine in Older Adults with Chronic Low Back Pain and Depression. Pain Medicine. Publisher Link

Brown V, Peciña M. Neuroimaging Studies of Antidepressant Placebo Effects: Challenges and Opportunities. Frontiers in Psychiatry. Publisher Link

Lin C, Karim HT, Peciña M, Aizenstein H, Lenze EJ, Blumberger DM, Mulsant B, Kharasch ED, Reynolds III CF, Karp JK. Low-dose augmentation with buprenorphine increases emotional reactivity but not reward activity in treatment resistant mid- and late-life depression. Neuroimage: Clinical. 2019; 21:101679. doi: 10.1016/j.nicl.2019.101679. Epub 2019 Jan 22.PMID: 30685701; PubMed Central PMCID: PMC6356006. Publisher Link

Peciña M, Karp JF, Mathew S, Todtenkopf MS, Ehrich EW, Zubieta JK. Endogenous opioid system dysregulation in depression: implications for new therapeutic approaches. Mol Psychiatry. 2019 Apr;24(4):576-587. Epub 2018 Jun 28. PubMed PMID: 29955162; PubMed Central PMCID: PMC6310672. Publisher Link

2018

Peciña M, Heffernan J, Wilson J, Zubieta JK, Dombrovski AY. Prefrontal expectancy and reinforcement-driven antidepressant placebo effects. Transl Psychiatry. 2018 Oct 15;8(1):222. doi: 10.1038/s41398-018-0263-y. PMID: 30323205; PubMed Central PMCID: PMC6189213. Publisher Link

Wilson RP, Colizzi M, Bossong MG, Allen P, Kempton M; MTAC., Abe N, Barros-Loscertales AR, Bayer J, Beck A, Bjork J, Boecker R, Bustamante JC, Choi JS, Delmonte S, Dillon D, Figee M, Garavan H, Hagele C, Hermans EJ; ICCAM Consortium., Ikeda Y, Kappel V, Kaufmann C, Lamm C, Lammertz SE, Li Y, Murphy A, Nestor L, Peciña M, Pfabigan D, Pizzagalli D, Rademacher L, Roee A, Sommer T, Stark R, Suzuki H, Van Amselvoort T, Van Hell E, Vink M, Votinov M, Wotruba D, Bhattacharyya S. The Neural Substrate of Reward Anticipation in Health: A Meta-Analysis of fMRI Findings in the Monetary Incentive Delay Task. Neuropsychol Rev. 2018 Sep 25. doi: 10.1007/s11065-018-9385-5. Review. PubMed PMID: 30255220; PubMed Central PMCID: PMC6310672. Publisher Link

Peciña M, Zubieta JK. Expectancy Modulation of Opioid Neurotransmission. Int Rev Neurobiol. 2018; 138:17-37. doi: 10.1016/bs.irn.2018.02.003. Epub 2018 Apr 2. PubMed PMID: 29681324; PubMed Central PMCID: PMC6314670. Publisher Link

2017

Peciña M, Sikora M, Avery ET, Heffernan J, Peciña S, Mickey BJ, Zubieta JK. Striatal Dopamine D2/3 Receptor-Mediated Neurotransmission in Major Depression: Implications for Anhedonia, Anxiety and Treatment Response. Eur Neuropsychopharmacol. 2017 Oct;27(10):977-986. doi: 10.1016/j.euroneuro.2017.08.427. Epub 2017 Sep 1. PubMed PMID: 28870407; PubMed Central PMCID: PMC5623119. Publisher Link

2016

Mickey BJ, Heffernan J, Heisel C, Peciña M, Hsu DT, Zubieta JK, Love TM. Oxytocin modulates hemodynamic responses to monetary incentives in humans. Psychopharmacology (Berl). 2016 Dec;233(23-24):3905-3919. Epub 2016 Sep 10. PubMed PMID: 27614896; PubMed Central PMCID: PMC5106343. Publisher Link

Romero M, Aguilar JM, Del-Rey-Mejias A, Mayoral F, Rapado M, Peciña M, Barbancho MA, Ruiz-Veguilla M, Lara JP. Psychiatric comorbidities in autism spectrum disorder: A comparative study between DSM-IV-TR and DSM-5 diagnosis. International Journal of Clinical and Health Psychology: IJCHP. 2016 Sep-Dec;16(3):266-275. doi: 10.1016/j.ijchp.2016.03.001. Epub 2016 Jun 3. PMID: 30487870; PMCID: PMC6225088. Publisher Link

Kassel MT, Rao JA, Walker SJ, Briceño EM, Gabriel LB, Weldon AL, Avery ET, Haase BD, Peciña M, Considine CM, Noll DC, Bieliauskas LA, Starkman MN, Zubieta JK, Welsh RC, Giordani B, Weisenbach SL, Langenecker SA. Decreased Fronto-Limbic Activation and Disrupted Semantic-Cued List Learning in Major Depressive Disorder. J Int Neuropsychol Soc. 2016 Apr;22(4):412-25. doi: 10.1017/S1355617716000023. Epub 2016 Feb 2. PubMed PMID: 26831638; PubMed Central PMCID: PMC4856469. Publisher Link

Jacobs RH, Barba A, Gowins JR, Klumpp H, Jenkins LM, Mickey BJ, Ajilore O, Peciña M, Sikora M, Ryan KA, Hsu DT, Welsh RC, Zubieta JK, Phan KL, Langenecker SA. Decoupling of the amygdala to other salience network regions in adolescent-onset recurrent major depressive disorder. Psychol Med. 2016 Apr;46(5):1055-67. doi: 10.1017/S0033291715002615. Epub 2016 Jan 20. PubMed PMID: 26784396; PubMed Central PMCID: PMC4810773. Publisher Link

Sikora M, Heffernan J, Avery ET, Mickey BJ, Zubieta JK, Peciña M. Salience Network Functional Connectivity Predicts Placebo Effects in Major Depression. Biol Psychiatry Cogn Neurosci Neuroimaging. 2016 Jan;1(1):68-76. PubMed PMID: 26709390; PubMed Central PMCID: PMC4689203. Publisher Link

2015

Peciña M, Bohnert AS, Sikora M, Avery ET, Langenecker SA, Mickey BJ, Zubieta JK. Placebo-Activated Neural Systems are Linked to Antidepressant Responses: Neurochemistry of Placebo Effects in Major Depression. JAMA Psychiatry. 2015 Nov;72(11):1087-94. doi: 10.1001/jamapsychiatry.2015.1335. PubMed PMID: 26421634; PubMed Central PMCID: PMC4758856. Publisher Link

Martikainen IK, Nuechterlein EB, Peciña M, Love TM, Cummiford CM, Green CR, Stohler CS, Zubieta JK. Chronic Back Pain Is Associated with Alterations in Dopamine Neurotransmission in the Ventral Striatum. J Neurosci. 2015 Jul 8;35(27):9957-65. doi: 10.1523/JNEUROSCI.4605-14.2015. PubMed PMID: 26156996; PubMed Central PMCID: PMC4495244. Publisher Link

Peciña M, Zubieta JK. Molecular Mechanisms of Placebo Responses In Humans. Mol Psychiatry. 2015 Apr;20(4):416-23. doi: 10.1038/mp.2014.164. Epub 2014 Dec 16. Review. PubMed PMID: 25510510; PubMed Central PMCID: PMC4372496. Publisher Link

Peciña M, Zubieta JK. Over a decade of neuroimaging studies of placebo analgesia in humans: what is next? Mol Psychiatry. 2015 Apr;20(4):415. doi: 10.1038/mp.2015.33. PubMed PMID: 25798855. Publisher Link

2014

Peciña M, Love T, Stohler CS, Goldman D, Zubieta JK. Effects of the Mu Opioid Receptor Polymorphism (OPRM1 A118G) on Pain Regulation, Placebo Effects and Associated Personality Trait Measures. Neuropsychopharmacology. 2015 Mar;40(4):957-65. doi: 10.1038/npp.2014.272. Epub 2014 Oct 13. PubMed PMID: 25308352; PubMed Central PMCID: PMC4330509. Publisher Link

Schallmo MP, Kassel MT, Weisenbach SL, Walker SJ, Guidotti-Breting LM, Rao JA, Hazlett KE, Considine CM, Sethi G, Vats N, Peciña M, Welsh RC, Starkman MN, Giordani B, Langenecker SA. A New Semantic List Learning Task to Probe Functioning of the Papez Circuit. J Clin Exp Neuropsychol. 2015;37(8):816-33. doi: 10.1080/13803395.2015.1052732. PubMed PMID: 26313512; PubMed Central PMCID: PMC5065919. Publisher Link

Peciña M, Stohler CS, Zubieta JK. Neurobiology of placebo effects: expectations or learning? Soc Cogn Affect Neurosci. 2014 Jul;9(7):1013-21. doi: 10.1093/scan/nst079. Epub 2013 Jul 24. PubMed PMID: 23887819; PubMed Central PMCID: PMC4090967. Publisher Link

Peciña M, Martínez-Jauand M, Love T, Heffernan J, Montoya P, Hodgkinson C, Stohler CS, Goldman D, Zubieta JK. Valence-Specific Effects of BDNF Val66Met Polymorphism on Dopaminergic Stress and Reward Processing in Humans. J Neurosci. 2014 Apr 23;34(17):5874-81. doi: 10.1523/JNEUROSCI.2152-13.2014. PubMed PMID: 24760847; PubMed Central PMCID: PMC3996214. Publisher Link

Peciña M, Martínez-Jauand M, Hodgkinson C, Stohler CS, Goldman D, Zubieta JK. FAAH selectively influences placebo effects. Mol Psychiatry. 2014 Mar;19(3):385-91. doi: 10.1038/mp.2013.124. Epub 2013 Sep 17. PubMed PMID: 24042479; PubMed Central PMCID: PMC4222079. Publisher Link

2013

Martikainen IK, Peciña M, Love TM, Nuechterlein EB, Cummiford CM, Green CR, Harris RE, Stohler CS, Zubieta JK. Alterations in Endogenous Opioid Functional Measures in Chronic Back Pain. J Neurosci. 2013 Sep 11;33(37):14729-37. doi: 10.1523/JNEUROSCI.1400-13.2013. PubMed PMID: 24027273; PubMed Central PMCID: PMC3771036. Publisher Link

Briceño EM, Weisenbach SL, Rapport LJ, Hazlett KE, Bieliauskas LA, Haase BD, Ransom MT, Brinkman ML, Peciña M, Schteingart DE, Starkman MN, Giordani B, Welsh RC, Noll DC, Zubieta JK, Langenecker SA. Shifted Inferior Frontal Laterality in Women with Major Depressive Disorder is Related to Emotion Processing Deficits. Psychol Med. 2013 Jul;43(7):1433-45. doi: 10.1017/S0033291712002176. Epub 2013 Jan 8. PubMed PMID: 23298715; PubMed Central PMCID: PMC4380502. Publisher Link

Peciña M, Mickey BJ, Love T, Wang H, Langenecker SA, Hodgkinson C, Shen PH, Villafuerte S, Hsu D, Weisenbach SL, Stohler CS, Goldman D, Zubieta JK. DRD2 polymorphisms modulate reward and emotion processing, dopamine neurotransmission and openness to experience. Cortex. 2013 Mar;49(3):877-90. doi: 10.1016/j.cortex.2012.01.010. Epub 2012 Feb 14. PubMed PMID: 22424959; PubMed Central PMCID: PMC3381848. Publisher Link

Peciña M, Azhar H, Love TM, Lu T, Fredrickson BL, Stohler CS, Zubieta JK. Personality Trait Predictors of Placebo Analgesia and Neurobiological Correlates. Neuropsychopharmacology. 2013 Mar;38(4):639-46. doi: 10.1038/npp.2012.227. Epub 2012 Nov 16. PubMed PMID: 23187726; PubMed Central PMCID: PMC3572460. Publisher Link

Peciña M, Stohler CS, Zubieta JK. Role of μ-Opioid System in the Formation of Memory of Placebo Responses. Mol Psychiatry. 2013 Feb;18(2):135-7. doi: 10.1038/mp.2012.16. Epub 2012 Mar 20. PubMed PMID: 22430673; PubMed Central PMCID: PMC4152848. Publisher Link

2012

Love TM, Enoch MA, Hodgkinson CA, Peciña M, Mickey B, Koeppe RA, Stohler CS, Goldman D, Zubieta JK. Oxytocin Gene Polymorphisms Influence Human Dopaminergic Function in a Sex Dependent Manner. Biol Psychiatry. 2012 Aug 1;72(3):198-206. doi: 10.1016/j.biopsych.2012.01.033. Epub 2012 Mar 13. PubMed PMID: 22418012; PubMed Central PMCID: PMC3392442. Publisher Link

Hsu DT, Mickey BJ, Langenecker SA, Heitzeg MM, Love TM, Wang H, Kennedy SE, Peciña M, Shafir T, Hodgkinson CA, Enoch MA, Goldman D, Zubieta JK. Variation in the Corticotropin-Releasing Hormone Receptor 1 (CRHR1) Gene Influences fMRI Signal Responses during Emotional Stimulus Processing. J Neurosci. 2012 Feb 29;32(9):3253-60. doi: 10.1523/JNEUROSCI.5533-11.2012. PubMed PMID: 22378896; PubMed Central PMCID: PMC3297975. Publisher Link

Mickey BJ, Zhou Z, Heitzeg MM, Heinz E, Hodgkinson CA, Hsu DT, Langenecker SA, Love TM, Peciña M, Shafir T, Stohler CS, Goldman D, Zubieta JK. Emotional processing, major depression, and functional genetic variation of neuropeptide Y. Arch Gen Psychiatry. 2011 Feb;68(2):158-66. doi: 10.1001/archgenpsychiatry.2010.197. PubMed PMID: 21300944; PubMed Central PMCID: PMC3091621. Publisher Link